His parents are of Urdu-speaking (Muhajir) background. Rizwan Ahmed was born on 1 December 1982 in Wembley, in the London borough of Brent, to a British Pakistani family. In 2017, he was included on the front cover of the annual Time 100 list of the world's most influential people.
As an activist, he is known for his political rap music, has been involved in raising awareness and funds for Rohingya and Syrian refugee children, and has advocated for representation at the House of Commons. In 2020, Ahmed released The Long Goodbye, a critically acclaimed album with an award-winning accompanying short film. Īs a musician he was formerly known by his stage name Riz MC, he was a member of the Swet Shop Boys, earned critical acclaim with the hip hop albums Microscope and Cashmere, and earned commercial success with the US Billboard 200-topping Hamilton Mixtape, with his song " Immigrants (We Get the Job Done)" winning an MTV Video Music Award. He went on to play Carlton Drake in the film Venom (2018), and Ruben Stone in Sound of Metal (2020), the latter of which earned him widespread critical acclaim, his second Golden Globe nomination (following The Night Of) and his first Academy Award nomination, making him the first Muslim to be nominated for Best Actor.
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At the 2017 Emmy Awards, he received two nominations, for his performance in The Night Of and his guest role in Girls he won the award for Outstanding Lead Actor in a Limited Series or Movie for the former, becoming the first Asian male to win an acting Emmy, and the first Muslim and first Asian to win a lead acting Emmy.
He also starred as a young man accused of murder in the HBO miniseries The Night Of, earning critical acclaim. In 2016, he appeared in the action film Jason Bourne, and played Bodhi Rook in the Star Wars Anthology film Rogue One. He was initially known for his work in independent films such as The Road to Guantanamo (2006), Shifty (2008), Four Lions (2010), Trishna (2011), Ill Manors (2012), and The Reluctant Fundamentalist (2013), as well as television series such as Britz (2007) and Dead Set (2008), before his breakout role in the film Nightcrawler (2014) and The Night Of (2016). As an actor, he has won a Primetime Emmy Award, National Board of Review Award for Best Actor, Independent Spirit Award for Best Male Lead, London Film Critics' Circle Award for British Actor of the Year, and received nominations for an Academy Award, two Golden Globe Awards, two Emmy Awards, two Screen Actors Guild Awards, and three British Independent Film Awards. Further 42 did not affect motor coordination up to doses of 1000 mg/kg, demonstrating a wide therapeutic margin.Rizwan Ahmed (born 1 December 1982) is a British actor and rapper. 2009, 52, 3047 - 3062) was confirmed as an iNOS dimerization inhibitor and was efficacious in the mouse formalin model of nociception and Chung model of neuropathic pain, without showing tolerance after repeat dosing. Compounds were triaged utilizing an LPS challenge assay coupled with mouse and rhesus pharmacokinetics and led to the identification of 4,7-imidazopyrazine 42 as the lead compound. By conformationally restricting the amide of this progenitor series, we describe the identification of a novel series of benzimidazole-quinolinone dual iNOS/nNOS inhibitors with low clearance and sustained exposure in vivo. Previously, we described the identification of a series of amide-quinolinone iNOS dimerization inhibitors that although potent, suffered from high clearance and limited exposure in vivo. Inappropriate or excessive NO produced by iNOS and/or nNOS is associated with inflammatory and neuropathic pain. Three isoforms of nitric oxide synthase (NOS), dimeric enzymes that catalyze the formation of nitric oxide (NO) from arginine, have been identified.
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